Developing a Strategy to Optimise Active Pharmaceutical Ingredient Filtration and Washing

摘要

Filtration, washing & drying in pharmaceutical development are non-trivial operations There is limited availability of appropriate continuous filtration, washing and drying equipment for pharmaceutical applications especially at the interface between development and manufacturing. A development methodology has been outlined: Material Methodology Machine Some challenges remain: Removal of structurally related impurities from "hard to filter crystals" Refining the wash solvent selection strategy Demonstrate data driven process development methodology