Structure/Function Relations of Hemostatic Nonwoven Dressings Based on Greige Cotton

摘要

A variety of natural and synthetic fibers are employed in hemostatic dressings. Here we demonstrate the use of greige cotton as a functional fiber, which when combined with hydrophilic and hydrophobic fibers in hydroentangled nonwoven materials, promotes accelerated clotting. A biophysical approach was developed to identify fiber compositions that promote hemostasis. The structure/function characterization of greige cotton-based dressings was based on the relationship of material electrokinetics to the rate of fibrin and clot formation. When coupled to material absorption capacity and wicking determinations, materials that promote a rapid onset of clotting were identified. In vitro assessment of whole materials that promote hemostasis was completed using the Lee White Clotting assay to provide a structure versus function profile of hemostatic activity for selection of leads.