Nanopore DNA Sequencing Channel Modeling

摘要

In this paper we first present a simplified DNA storage chain (partially inspired by the classical digital communication principles) and review the last advances on error-correcting codes for DNA storage. We then introduce a novel DNA channel model for a new generation of nanopore sequencers. For this, we analyze the reported experimental results to define and characterize an original DNA sequencing channel model. This contribution opens new directions in the design of efficient error-correcting codes to improve the performance of DNA-based data storage.