Novel concepts for efficient and predictable membrane separation in continuous cell retention and downstream processing

摘要

1. Based on selected results presented, novel membrane concepts appear to be candidates for stable bioprocess operation with cell retention and/or protein separation. Validation for pharmaceutical biotech processes is required. 2. Novel modules and processing modes both yield options for process intensification by minimizing deposit formation. 3. New insights gained in this work are important for continuous operation of biological processes, where high flux and a defined, stable permeation/low retention of target substances over long periods are key. 4. Benchmarking results and methodology for process optimization between food process and bioprocess engineering could result in higher overall bioprocess productivities by avoiding of operational bottlenecks.