DIGITALIZATION PLATFORM AND SUPERVISORY CONTROL OF A CONTINUOUS INTEGRATED BIOPROCESS BASED ON RAMAN SPECTROSCOPY

摘要

In the last years, the implementation of Raman spectroscopy, multivariate data analysis (MVDA) and advanced control algorithms gained increasing interest in the biopharmaceutical industry through the PAT initiative. However, there is still a huge gap towards an efficient implementation of modern process analyzers, a centralized data mining combined with online use of MVDA and the integration of process knowledge into a supervisory control frame.