Development and large scale manufacturing of exosome-based therapeutics

摘要

1. Many "-somes" in the literature 2. Exosomes, endosomes, ectosomes. oncosomes, dectosomes, connectosomes, gohstosomes, vexosomes, FedExosomes,... 3. No standard definition translatable into characterization methods 4. Typical exosome attributes Size (40-200 nm) a. Canonical surface proteins (CD9, CD47, CD63, CD81, etc.) b. Relevant functional assays (uptake, biodistribution, etc.) c. However, above attributes overlap with other Extracellular Vesicles.