Using Networks to Link Genotype to Phenotype

摘要

We know that genotype influences phenotype, but aside from a few highly penetrant Mendelian disorders, the link between genotype and phenotype is not well understood. We have used gene expression and genetic data to explore gene regulatory networks, to study phenotypic state transitions, and to analyze the connections between genotype and phenotype. I will describe how networks and their structure provide unique insight into how small effect variants influence phenotype.