Rapid liquefaction of blood clots using histotripsy in an in vivo porcine intracerebral hemorrhage (ICH) model

摘要

Histotripsy is a noninvasive ultrasound therapy that fractionates target tissues via cavitation. Our group has previously demonstrated that histotripsy can be delivered transcranially through excised human skulls to rapidly liquefy large volume clots for catheter aspiration using electronic focal steering (up to 40mL in 20 min) in an ex vivo ICH model. Transcranial MRgFUS has been investigated for ICH treatment, but is much slower (40mL in 3 hours), and limited to deep targets due to prefocal skull heating. The objective of this study was to demonstrate the feasibility of using histotripsy to liquefy clots for catheter aspiration in an in vivo porcine ICH model.