Histotripsy produced by dual frequency of fundamental and harmonic superimposition with protocol of hundred-microsecond-length pulses and two stages

摘要

Histotripsy is a new non-invasive therapy modality and can mechanically disintegrating target tissue for tumor treatment. In this study, we propose a strategy of dual frequency of fundamental and harmonic superimposition combined with hundred-microsecond-length pulses and two stages to get good use of the nonlinear regimes of enhanced cavitation and boiling. Confocal fundamental and harmonic superimposition can greatly lower the cavitation threshold and enhance cavitation activity via wave interference.