Behavior of the oscillating microbubble clusters trapped in focused ultrasound field

摘要

Microbubbles (MBs) are widely used in clinical site as contrast agents in ultrasound imaging due to its eminent responsiveness to several MHz band. In recent years, ultrasound drug delivery system (DDS) using MBs are widely researched to achieve selective medication to the targeted diseased part. In the condition of high number density of bubbles to enhance the performance of DDS, it is essentially important to understand interaction between bubbles and establish a control method of bubble clusters. In previous works, we can manipulate MBs using focused ultrasound, forming a bubbles cluster at the focus of the ultrasound field. The purpose of this study is to clarify scaling behavior of bubble clusters with various physical properties, since such scaling parameters is highly relating various bubble parameters which have not been measured in other methods.