Simulation of insulin regimen and glucose profiles in Type 1 diabetic patient

摘要

A composite model, describing the glucose/insulin dynamics following daily food administration and insulin injections in Type 1 Diabetes Mellitus patients is presented. Three daily meals have been simulated, food intake representing four different types of foodstuffs, along with three rapid-acting insulin injections and one long-acting insulin injection. Three different scenarios (depending on whether food intake and/or administration times were fixed or random) were hypothesized: simulations show a very realistic time-course for both glucose and insulin dynamics over long (20 days) and short (one day) time periods.