COMPUTATIONAL HEMODYNAMIC ASSESSMENT OF A NOVEL MODULAR ANASTOMOTIC VALVE DEVICE FOR IMPROVING HEMODIALYSIS VASCULAR ACCESS PATENCY

摘要

The present results indicate the existence of limited areas of both high and low WSS in the open MAVD configuration (i.e., intra-dialysis periods). Over the life of the therapy, these results show a　significant decrease in WSS and flow abnormalities as compared to traditional HD therapies which leave arterial flow constantly coming into the vein, instead of just during HD treatments. This confirms the ability of the MAVD concept to normalize the flow between hemodialysis periods. Based on the present results, this novel technology has the potential to offer significant improvements to vascular access patency over arteriovenous fistulas and grafts. Ongoing work includes the refinement of the flow simulations via the inclusion of the vein compliance and associated fluid-structure interactions, as well as ex vivo experiments aimed at characterizing the effects of MAVD WSS on intimal hyperplasia pathogenesis.