Comparison of 4-class and Continuous Fat/Water Methods for Whole-Body, MR-Based PET Attenuation Correction

摘要

The goal of this study was to compare two approaches for MR-based PET patient attenuation correction (AC) in whole-body FDG-PET imaging using a tri-modality PET/CT & MR setup. Sixteen clinical whole-body FDG patients were included in this study. Mean standard uptake values (SUV) were measured for liver and lung volumes-of-interest for comparison. Maximum SUV values were measured in 18 FDG-avid features in ten of the patients. The AC methods compared to gold-standard CT-based AC were segmentation of the CT (air, lung, fat, water), MR image segmentation with 4 tissue classes (air, lung, fat, water) and segmentation with air, lung and a continuous fat/water method. Results: The magnitude of uptake value differences induced by CT-based image segmentation were similar but lower on average than those found using the MR-derived AC methods. The average liver SUV difference with that found using CTAC was 1.3%, 10.4% and 5.7% for 4-class segmented CT, 4-class MRAC and continuous fat/water MRAC methods, respectively. The average FDG-avid feature SUV_(max) difference was -0.5%, 1.7% and -1.6% for 4-class segmented CT, 4-class MRAC and continuous fat/water MRAC methods, respectively. Conclusion: The results demonstrated that both 4-class and continuous fat/water AC methods provided adequate quantitation in the body, and that the continuous fat/water method was within 5.7% on average for SUV_(mean) in liver and 1.6% on average for SUV_(max) for FDG-avid features.