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Differential phase-contrast tomosynthetic experimental system with weakly coherent hard X-rays

机译:具有弱相干硬X射线的差分相位对比度自动化实验系统

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Hard X-ray phase-contrast imaging can provide high sensitivity of weakly absorbing low-Z objects in medical and biological fields. Grating-based differential phase-contrast (DPC) method which relies on Talbot self-imaging effect have been paid more attention because it can work with conventional X-ray tube and show great potential for clinic use. Meanwhile tomosynthesis as a 3D reconstruction method is especially useful in mammography where low does is necessary. In this paper, an phase-contrast tomosynthetic experimental system is implemented based on the differential phase contrast imaging method according to moiré deflectometry (named MD-DPC method) with weakly coherent hard X-rays. The source grating of former grating-based method can perhaps be removed and the energy utilization efficiency of the X-ray tube is increased. The effectiveness of MD-DPC method is proved by actual experiments. In our phase-contrast tomosynthetic experimental system, the x-ray tube and the detector is stationary while the sample is rotated on a rotation stage, which is equivalent to conventional linear tomosynthesis. However, for phase contrast image, the refraction-angle is the line integral of differentials of refractive index decrement in the sample along the beam path whose vector direction is vary as the tomosynthetic projection direction changes, so refraction-angle projections can’t be simply added up like scalar quantities as in conventional tomosynthesis. A mapping method is adopted here to map each refraction-angle projection to the same direction and then refraction-angle tomosynthetic images can be implemented by adopting the shift-and-add approach. Our experimental system is validated and phase-contrast tomosynthesis based MD-DPC would be considered as a promising imaging method for mammography to enhance the contrast of early cancer tissues in the near future.
机译:硬X射线相位对比度成像可以提供高敏感性的医学和生物领域的低Z对象的高灵敏度。基于光栅的差分相位对比度(DPC)方法依赖于Talbot自成像效果,因为它可以使用传统的X射线管,并显示出临床使用的巨大潜力。与此同时,随着3D重建方法的造成乳房X线照相,在乳房X线摄影中是必要的。本文基于根据莫尔义偏移量(命名MD-DPC方法)的差分相位对比成像方法,实现了相对造影性造影性实验系统,其具有弱相干的硬X射线。以前基于光栅的方法的源光栅可能被移除,并且X射线管的能量利用效率增加。通过实际实验证明了MD-DPC方法的有效性。在我们的相位对比度造影性实验系统中,X射线管和检测器是静止的,而样品在旋转级旋转,这相当于传统的线性自成件合成。然而,对于相位对比图像,折射角度是沿着其矢量方向改变作为断层合成投影方向的改变的光束路径中的样品中的折射率递减的微分的线积分,所以折射角度的突起不能简单在传统的造型中添加了标量数量。这里采用映射方法来将每个折射角投影映射到相同的方向,然后可以通过采用移位和添加方法来实现折射角度的自动化图像。我们的实验系统是验证的,并且基于相位对比的自然的MD-DPC将被认为是乳房X线摄影的有望成像方法,以在不久的将来增强早期癌组织的对比度。

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