Overall Survival Analyzer: A software tool to analyze genotyping and clinical data enriched with temporal events

摘要

The estimation of survival distributions of patients is an important current problem in clinical oncology. The current trend is to integrate molecular data (such as genomic data) with clinical data (e.g. cancer type, stage of the disease, etc) and then to link survival distributions to molecular profile of patients. Recently, the Affymetrix DMET (Drug Metabolizing Enzymes and Transporters) microarray technology has enabled the possibility to determine the allelic variants of a patient and to relate them to phenotype (e.g. drug toxicity). Therefore, the analysis of survival distribution of patients starting from their profile obtained using DMET data may reveal important knowledge to clinicians. In order to provide support to this analysis we propose Overall Survival Analyzer (OS-Analyzer), a software tool able to compute the Overall Survival and Progression-Free Survival (PFS). The tool is able to perform an automatic analysis of data avoiding wasting time on the manual analysis. OS-Analyzer is available to download at the follows web address: https://sites.google.com/site/overallsurvivalanalyzer/.