To investigate stiff person syndrome(SPS) in Chinese patients. Combining 192 patients currently reported in China with previous literature review, the authors report the disease incidence, pathogenesis, clinical manifestation, treatment methods, causes of death and related research progress. The occurrence of this disease is mainly due to influenza and tumor induced, characterized by fluctuating muscle rigidity and spasm of features. It often influences trunk and limb muscles. When respiratory muscle is affected, it would lead to death. In conclusion, SPS is a disease which may relate to immune system. Its diagnosis mainly relies on the examination of clinical symptoms. Benzodiazepines can be used as experimental medication and electromyography is also of great significance. Finally, benzodiazepines and TCM are both effective methods of treatment.
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