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Levofloxacin Release, Antibacterial Activity and Cytotoxicity Studies on a Novel Wound Dressing

机译:新型伤口敷料中左氧氟沙星的释放,抗菌活性和细胞毒性研究

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摘要

A novel functional material was fabricated by combining levofloxacin microspheres with viscose nonwoven fabrics.The complex microspheres were made by w/o emulsion crosslinking technique.The morphologies of both microspheres and fabric composite were investigated by SEM.The drug release property was evaluated by UV.The antibacterial activity and cytotoxicity were tested by spread plate and cell culture method.The results showed that the microspheres had spherical shape and could be embedded into the viscose fabrics.The levofloxacin was released gradually within 168 hours and its release kinetics corresponded to diffusion-relaxation model.In addition,the antibacterial activity of the fabric was increased with prolonged drug releasing time and the complex fabrics had no obvious cytotoxicity.The functional material has great potential to be used as a wound dressing with antibacterial property.
机译:将左氧氟沙星微球与粘胶无纺布结合制成一种新型功能材料,采用无水乳液交联技术制备了复合微球,并通过SEM研究了微球和织物复合物的形貌,并通过紫外光评价了药物的释药性能。用平板扩散法和细胞培养法检测了抗菌活性和细胞毒性。结果表明,微球呈球形,可以包埋在粘胶织物中。左氧氟沙星在168小时内逐渐释放,其释放动力学与扩散松弛相对应。此外,织物的抗菌活性随药物释放时间的延长而增加,并且复杂的织物没有明显的细胞毒性。该功能材料具有用作具有抗菌特性的伤口敷料的巨大潜力。

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