Brain Activity Movie functional MRI with ultra-high temporal resolution at 7 Tesla

摘要

Increased signal changes in blood oxygen dependant (BOLD) weighted functional magnetic resonance imaging (fMRI) data sets at ultra-high field strengths enable an increase in spatial and temporal resolution. Here we examine activation patterns in the human motor cortex on a 7 Tesla scanner employing temporal resolutions of 100ms, 200ms and 300ms, respectively. Based on Finite-impulse response (FIR) analysis we generate Brain Activity Movies (BAMs) to allow for explorative assessment of activation topology. We find that time courses of activation in primary motor cortex (Ml), supplementary motor area (SMA) and pre-SMA are very similar across temporal resolutions despite considerable differences in signal-to-noise ratios.