Both schemes can extract quantitative information about fiber orientation in the LC, and thus have the potential to quantify LC connective tissue changes (e.g. secondary to ocular hypertension) and drive biomechanical modelling of the normal and glaucomatous ONH. The SALS approach is feasible in post mortem human eyes, with a pseudo-3D representation achievable by assembly of data from sections through the LC. The nCT/DFFT approach provided fibre orientation results consistent with those obtained with SALS. It is advantageous with respect to the SALS approach because it can easily be extended to provide true 3D orientation data. The |iCT approach also provides anatomical information and tissue preparation is simple, making iCT an attractive imaging methodology for studying LC morphology and biomechanics.
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