MULTIDOMAIN MODELING OF SPATIAL DISTRIBUTIONS OF TISSUE OPTICAL PROPERTIES DURING INDENTATION: MECHANICAL TISSUE OPTICAL CLEARING DEVICES AS DIAGNOSTIC TOOLS

摘要

Soft tissues are highly heterogeneous materials comprised of water, proteins, and many types of cells. This composite configuration results in a large mismatch in index of refraction between tissue constituents, creating a high-scattering medium in the visible and near-infrared range.