A multi-residue method for fast determination of 78 pesticides in cranberry extract by gas chromatography triple quadripole mass spectrometry with quechers sample preparation

摘要

A rapid multi-residue method based on the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) sample preparation method and gas chromatography triple quadrupole tandem mass spectrometry (GC/MS/MS) for the analysis of 78 pesticide residues in cranberry extract has been developed. The method involved extraction with acetone (containing 1 % acetic acid): n-hexane (1∶1, V/V), followed by primary secondary amine (PSA) and graphitized carbon black (GCB) clean up. The analyses were carried out with GC/MS/MS. The method was validated using cranberry extract spiked at 0.01 mg·kg−1, 0.05 mg·kg−1 and 0.1 mg·kg−1 and the average recovery by the method varied from 69.5% to 115.8% with RSDs < 16.6%. The method showed good linearity and the LOQs for the pesticides studied were lower than 31.5 µg·kg−1. This method was successfully applied to analysis cranberry extract samples.