Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

摘要

Chitosan exhibits antimicrobial activities through its interaction(s) with microbial cell surface thereby altering their gene expression and cellular function, leading to cell death. Nanometal particles exert many effects not previously expected on biological systems and thus can be explored for diverse biomedical applications. Our previous and on-going studies indicate that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured alone. In this study we tested the hypothesis that the inhibitory effect of chitosan is enhanced if combined with nanometals and Adriamycin, a common anticancer durg. Our results showed that combinations of metal nanoparticles, Adriamycin and chitosan induced decreased survival of U87 glioma cells at different rates, more marked than those with chitosan alone. Thus, our results have pathophysiological implications in inhibiting human brain glioma invasion and migration.