Denoising of MR spectroscopic imaging data with spatial-spectral regularization

摘要

Low signal-to-noise ratio has been a significant limitation for clinical applications of magnetic resonance spectroscopic imaging (MRSI). This paper investigates a new scheme for denoising MRSI data, incorporating both an anatomically-adapted spatial-smoothness constraint and an autoregressive spectral constraint within the penalized maximum-likelihood framework. Both theoretical analysis and simulation results are provided to characterize the denoising performance of this approach.