Non-invasive detection of hypoglycemic episodes in Type 1 diabetes using intelligent hybrid rough neural system

摘要

Insulin-dependent diabetes mellitus is classified as Type 1 diabetes and it can be further classified as immunemediated or idiopathic. Through the analysis of electrocar-diographic (ECG) signals of 15 children with T1DM, an effective hypoglycemia detection system, hybrid rough set based neural network (RNN) is developed by the use of physiological parameters of ECG signal. In order to detect the status of hypoglycemia, the feature of ECG of type 1 diabetics are extracted and classified according to corresponding glucose levels. In this technique, the applied physiological inputs are partitioned into predicted (certain) or random (uncertain) parts using defined lower and boundary of rough regions. In this way, the neural network is designed to deal only with the boundary region which mainly consists of a random part of applied input signal causing inaccurate modeling of the data set. A global training algorithm, hybrid particle swarm optimization with wavelet mutation (HPSOWM) is introduced for parameter optimization of proposed RNN. The experiment is carried out using real data collected at Department of Health, Government of Western Australia. It indicated that the proposed hybrid architecture is efficient for hypoglycemia detection by achieving better sensitivity and specificity with less number of design parameters.