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Diffuse Axonal Injury And Degradation In Mechanical Characteristics Of Brain White Matter

机译:弥漫性轴索损伤和脑白质力学特性下降

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Diffuse Axonal Injury (DAI) can happen due to sudden motions of head and is one of the major causes of fatality and severe disabilities. To study DAI, any change in material characteristics of brain tissue post injury needs to be well understood. In this study, the focus will be on changes in the viscoelastic material properties of white mater in the brain due to DAI resulting in axonal disconnections. Using a micromechanics fibrous composite modeling for white mater, we have developed an algorithm to analyze the effect of discontinuity due to breakage of axons inside the surrounded matrix. Repeated unit ceil (RUC) was assumed to represent the axonal distribution within the extracellular matrix. Relaxation test were conducted for characterization of the viscoelastic behavior. The result of this study provides a modeling technique for characterization of injured brain tissue in white mater and proposes necessity of including the appropriate post injury axonal mechanical properties. These findings can improve the understanding of injury from mechanical perspective and help in predicting vulnerability of any such injured tissue against further injuries.
机译:弥漫性轴索损伤(DAI)可能由于头部突然运动而发生,并且是导致死亡和严重残疾的主要原因之一。要研究DAI,需要充分了解损伤后脑组织物质特征的任何变化。在这项研究中,重点将放在由于DAI导致轴突断开而导致大脑中白色物质的粘弹性材料特性的变化上。使用针对白色材料的微力学纤维复合材料建模,我们开发了一种算法来分析由于周围基质内部轴突断裂而引起的不连续性影响。假定重复单位细胞(RUC)代表细胞外基质内的轴突分布。进行松弛试验以表征粘弹性行为。这项研究的结果提供了一种建模技术,用于表征白色母体中受伤的脑组织,并提出了包括适当的损伤后轴突力学性能的必要性。这些发现可以从机械角度提高对损伤的理解,并有助于预测任何此类受伤组织对进一步损伤的脆弱性。

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