In recent years, anti-angiogenic therapy has been extensively Studied in both preclinical and clinical settings. Experimental studies have approved its effects on the normalization of rumor vasculature as well as the microenvironment in tumors [1]. However, little is known about how tumor microenvironment is affected by the changes in Structure of vasculature or transport properties of vessels and interstitium that are associated with anti-angiogenic therapy, since the experimental data are difficult to obtain [2].The purpose of this paper is to develop one numerical method to investigate the effects of vascular normalization by anti-angiogenic therapy on the improvement or normalization of tumor microenvironment. The study is based on two mathematical models of (1) tumor angiogenesis and (2) tumor haemodynamics. Figure 1 describes the major structure of the study.
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