This work investigates the effects of insonating pressure on ultrasound phase velocity in the SonoVueÃÂÿ microbubble suspension. Ultrasound transmission measurements were carried out using a single element transducer and calibrated needle hydrophone, for a range of SonoVueÃÂÿ concentrations from 50 to 800ÃÂÿl/l. Phase velocity was calculated using an established method based on the phase difference between pulses transmitted through the contrast agent and reference pulses for a range of insonating pressures from 13 to 128 kPa. Phase velocity was shown to be dependent on frequency, insonating pressure and SonoVueÃÂÿ concentration. The relationship between pressure and phase velocity was found to be approximately linear, with the pressure-velocity gradient increasing with concentration. These results may have significant implications for contrast-enhanced ultrasonography, for example in understanding artifact generation and quantitative applications such as estimating local bubble concentration.
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机译:这项工作调查了声压对超声速在SonoVue ÂÂ, sup>微气泡悬浮液中的影响。使用单元素换能器和校准的针式水听器进行超声波传输测量,测量SonoVue浓度范围从50到800 / l / l l。在13到128 kPa的声压范围内,基于通过造影剂传输的脉冲与参考脉冲之间的相位差,使用既定方法计算相速度。结果表明,相速度取决于频率,声波压力和SonoVue âⶠsup>浓度。发现压力和相速度之间的关系是近似线性的,压力-速度梯度随浓度而增加。这些结果可能对对比度增强型超声检查有重要意义,例如,在理解伪影的产生和定量应用(例如估计局部气泡浓度)方面。
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