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Two probabilistic methods to characterize and link drug related ECG changes to diagnoses from the PTB database: Results with Moxifloxacin

机译：从PTB数据库中表征和关联与药物相关的ECG变化与诊断的两种概率方法：莫西沙星的结果

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The QT interval is the lead biomarker for predicting risk of severe ventricular pro-arrhythmia in drug safety assessment. QT is a weak predictor, with no direct link to clinical endpoints.

机译：QT间隔是预测药物安全性评估中严重室性心律失常风险的主要生物标志物。 QT的预测能力较弱，与临床终点没有直接联系。

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《Computers in Cardiology, 2008 》|2008年|P.217-220|共4页
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Bousseljot R.; Kreiseler D.; Mensing S.; Safer A.;
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1. Period correction of the QTc of moxifloxacin with multiple predose baseline ECGs is the least variable of 4 methods tested. [J] . Zhang X, Silkey M, Schumacher M, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2009 ,第5期

机译：用多种给药前基线ECG对莫西沙星的QTc进行周期校正是所测试的4种方法中的最小变量。
2. Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin. [J] . Holzgrefe HH, Cavero I, Buchanan LV, Journal of Pharmacological and Toxicological Methods . 2007 ,第3期

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4. Two probabilistic methods to characterize and link drug related ECG changes to diagnoses from the PTB database: Results with Moxifloxacin [C] . Bousseljot R., Kreiseler D., Mensing S., Annual Computers in Cardiology Conference . 2008

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Two probabilistic methods to characterize and link drug related ECG changes to diagnoses from the PTB database: Results with Moxifloxacin

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