1-~(18)FFLUOROETHYLENEGLYCOL-2- NITROIMIDAZOLES: A NOVEL CLASS OF POTENTIAL HYPOXIA PET MARKERS

摘要

Several hypoxia markers contain a nitroimidazole moiety as the reactive chemical species, e.g. ~(18)FNIM [1], ~(18)FETNIM [2], ~(18)FMISO [3] or ~(18)FAZA [4]. It is believed that these imaging agents primarily enter tissue by diffusion and are trapped due to radical formation and subsequent intracellular reaction in the case of decreased oxygen concentration [5]. In particular, the blood brain barrier permeability is thought to play a crucial role in the cerebral uptake of the marker within hypoxia tissues [6].