Preparation of Nonradioactive Standards and a Precursor for a Hypoxia F-18 PET Tracer Derived from 1-(beta-D-Galactopyranosyl)-2-nitroimidazole

摘要

Acetyl-protected 1-(beta-D-galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6'-deoxy-6'-fluoro-galactosyl and the 4'-deoxy-4'-fluoroglucosyl analogue were also prepared. These 2-nitroimidazole nucleosides were prepared by a modified Vorbruggen coupling.