DETECTION OF DEEP VENOUS THROMBOSIS IN AN EXPERIMENTAL ANIMAL MODEL USING RADIOACTIVE LABELLED TIROFIBAN-GPIIb/IIIa INHIBITOR

摘要

and specificity were determined using the ratio 'left leg positive for DVT' and 'right leg negative for DVT'. The obtained ratio was 1.76 after 1 h, 1.99 after 3 h and 2.06 after 24 h in the case of iodine labelled tirofiban, and 1.54 after 30 min and 5.04 after 60 min with ~(99m)Tc-tirofiban. These values were considered as positive in the detection of acute DVT. The results from experimental studies show that radiolabelled tirofiban could be helpful in the further clinical investigation of patients with acute DVT.