Periodical Report for the Study of SARS CoV Transmitting Pathway Through Conjunctiva

摘要

Severe acute respiratory syndrome (SARS) has been spread rapidly over the world. Respiratory track and the digestive track had been known as the major transmission pathway of the SARS spreading. But knew very little about the other path, such as conjunctiva. Such sties are opening to the air,which makes the virus easily attached to the site. In this project,we investigated the SARS Coronavir-us(SARS CoV) presenting in the conjunctiva samples from different population to confirm whether the conjunctiva would be one of the transmission path for the SARS CoV spreading, whether there is virus carriers existing in the normal people in the disease epidemic area, and whether the conjunctiva swab would be a sensitive method for the SARS CoV determination in the early stage of the SARS CoV infection. We have collected numbers of the conjunctiva swab sample companied with the serum sample. Eyeballs from SARS dead cases were collected for the pathological study. Detective real time quantitative RT - PCR and RT- PCR plus sequencing would be performed, while the virus isolation with cell culture being pursued. Novel technology for the pathogen study is expected for collaboration from all available resources.