NANOPARTICLES FOR TARGETED DRUG DELIVERY TO THE INFLAMED MUCOSA IN EXPERIMENTAL COLITIS IN RATS

机译：大鼠实验性结肠炎中靶向药物递送至炎症黏膜的纳米颗粒

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Biodegradable nanoparticles of the anti-inflammatory drug rolipram mitigated experimental ulcerative colitis in rats after oral administration. The postulated prolonged residence in the inflamed area was proven by the reduced relapse of inflammation compared with the control group receiving drug solution. Moreover, a significant reduction of adverse effects was observed.

机译：口服给药后，抗炎药咯利普兰的可生物降解纳米颗粒减轻了大鼠实验性溃疡性结肠炎的发生。与接受药物溶液的对照组相比，发炎复发的减少证明了假定的在发炎区域的延长居住。此外，观察到不良反应显着降低。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.628-629|共2页
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A. Lamprecht; N. Ubrich; H. Yamamoto; U. Schaefer; H. Takeuchi; P. Maincent; Y. Kawashima; C.M. Lehr;
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中图分类基础医学;
关键词
nanoparticles; targeted delivery; colonic drug delivery; gastrointestinal transit;

机译：纳米粒子有针对性的交付;结肠给药胃肠道转运;

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1. Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis [J] . Iwao Yasunori, Tomiguchi Izumi, Domura Ayaka, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2018,第期

机译：基于人血清白蛋白纳米粒子与髓氧化酶在实验性结肠炎的小鼠模型中的人血清白蛋白纳米粒子相互作用的特异性药物递送系统
2. A novel protocol allowing oral delivery of a protein complement inhibitor that subsequently targets to inflamed colon mucosa and ameliorates murine colitis [J] . ElvingtonM., BlichmannP., QiaoF., Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2014,第2期

机译：一种新颖的方案，可以口服递送蛋白补体抑制剂，随后靶向发炎的结肠粘膜并改善小鼠结肠炎
3. Polymer-based drug delivery: the quest for local targeting of inflamed intestinal mucosa [J] . Dar M. Junaid, Ali Hussain, Khan Amjad, Journal of drug targeting . 2017,第1a10期

机译：基于聚合物的药物递送：寻求局部靶向发炎的肠粘膜
4. Design of a protease and ROS responsive biomaterial approach to target drug delivery in inflamed tissue microenvironment [C] . Gesmi Milcovich, Paolo Contessotto, Abhay Pandit World biomaterials congress . 2016

机译：在发炎的组织微环境中靶向药物递送的蛋白酶和ROS响应生物材料方法的设计
5. Cell targeted nanoparticle-based drug delivery systems for spinal cord injury regeneration [D] . Cerqueira, Susana R. 2013

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6. A novel protocol allowing oral delivery of a protein complement inhibitor that subsequently targets to inflamed colon mucosa and ameliorates murine colitis [O] . M Elvington, P Blichmann, F Qiao, 2014

机译：一种新的方案允许口服递送蛋白补体抑制剂随后靶向发炎的结肠粘膜并改善鼠科结肠炎
7. Nanoparticle-Based Oral Drug Delivery Systems Targeting the Colon for Treatment of Ulcerative Colitis [O] . Mingzhen Zhang, Didier Merlin 2018

机译：基于纳米粒子的口腔药物递送系统靶向结肠治疗溃疡性结肠炎
8. Peptides for Specific Intracellular Delivery and Targeting of Nanoparticles: Implications for Developing Nanoparticle-Mediated Drug Delivery [R] . 2010

机译：用于特异性细胞内递送和靶向纳米颗粒的肽：对开发纳米颗粒介导的药物递送的影响

NANOPARTICLES FOR TARGETED DRUG DELIVERY TO THE INFLAMED MUCOSA IN EXPERIMENTAL COLITIS IN RATS

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