Stabilization of polymeric drug carrier systems via disulfide bond formation

摘要

The stability of many polymeric drug carrier systems such as matrix tablets and microspheres is limited by an insufficient cohesiveness leading to a rapid disintegration of the polymeric network. Due to the subsequently strong increase in the surface area, on the one hand, the drug release out of the polymeric carrier system cannot be controlled any more (I). One the other hand, the protective effect of a polymeric carrier matrix for oral (poly)peptide delivery is strongly educed, if the dosage form disintegrates and intestinal proteases penetrate more easily into the polymeric network (II). Morover, mucoadhesive delivery systems won't remain on the mucosa if the adhesive bond fails within the polymeric network of the dosage form because of insufficient cohesive properties (III).