Spray-freeze drying to produce protein particles for encapsulation in polymer delivery systems

摘要

sustained release is an attractive alternative for proteins and peptides requiring frequent injections and has the potential to improve patient convenience, comfort and compliance. A recently FDA-approved example is Nutropin Depot~TM, recombinant human growth hormone in poly(lactide-co-glycolide) (PLG) microspheres. In this case, the zinc-complexed protein is spray-freeze dried and encapsulated in PLG using a cryogenic, non-aqueous process.~1