Pharmacoscintigraphic and pharmacokinetic evaluation of colon specific delivery system in healthy volunteers

摘要

Due to the lack of digestive enzymes and the long transit time, colon is considered as suitable site for the absorption of various drugs. Colon drug delivery system is useful in administering drugs that are irritant to the upper gastrointestinal tract such as non-steroidal anti-inflammatory agents, or drugs such as peptides that are degraded by gastric juice or an enzyme present in the upper gastrointestinal tract. Drugs for the treatment of colonic disease (e.g. diarrhea, constipation, IBD, Colon carcinoma) and chronotherapeutic drugs for rheumatoid arthritis, asthma, and hypertension will also benefit from incorporation into colon targeting systems. (1)