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Iontophoretic delivery of ropinirole HCl: effect of current density and vehicle formulation

机译:盐酸罗匹尼罗的离子电渗传递:电流密度和载体配方的影响

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Parkinson's disease is the third most common neurological disorder. Ropinirole 4-(2-(di-n-propylamino)ethyl)-1, 3-dihydro-2H-indol-2-one, monohydrochloride is a dopamine agonist that has been recently introduced into Parkinson's disease therapy (1). Ropinirole dose is tritrated for each patient in a stepwise procedure (2). An initial oral dose of 0.25 mg/8h is maintained for a week. Then, it is slowly increased in weekly increments of 0.75 mg a day until a satisfactory clinical response is observed (usually around 3-9 mg/day).
机译:帕金森氏病是第三大最常见的神经系统疾病。罗匹尼罗4-(2-(2-(二-正丙基氨基)乙基)-1,3-二氢-2H-吲哚-2-一,一盐酸盐是一种多巴胺激动剂,最近已被引入帕金森氏病治疗(1)。按逐步程序对每位患者的罗匹尼罗剂量进行滴定(2)。最初的口服剂量为0.25 mg / 8h维持一周。然后,以每天0.75 mg的每周增量缓慢增加,直到观察到令人满意的临床反应(通常约为3-9 mg / day)。

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