Effect of size on in vitro release of water insoluble drug from polilactofate microspheres

摘要

The release rate of a drug from polymer microspheres is of tremendous importance in formulating and developing appropriate and effective drug delivery systems. It is difficult to conduct a drug release study that occurs over prolonged periods of time. Drug release studies that can be completed in a single day to provide relevant information regarding the formulation and influence key decisions to be made relatively quickly are required. Also, it is difficult to quantify a drug that is insoluble in an aqueous or other medium. A proper release medium must be able to solubilize released drug in real time whiel not dissolving the formulation matrix. To achieve these goals, we have developed a medium (GPI-X buffer) that contains a solubility-enhancing agent to study the release of an insoluble drug substance from a polyphosphoester polymer microspheres formulation.