Mathematical model of the enzyme biosensor with multilayer charged membrane is developed. The charged layer of membrane is supposed to be penetrable for any particles and formed by built-in uniformly distributed charge. The Michaelis-menten theory is used for desription of the reaction velocity. The model is reducted to one-dimensional initial boundary value problem for the system of second-order partial differential equations describing diffusion-drift transoport of reaction components and products in memberane and Poission equation for e lectrostatic potential. The discrete model is constructed. The results of numerical experiment are in good qualitative fit with results of physical one. Created package can be easily adopted for memberanes with any number of layers.
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