Nifedipine penetration through human epidermis

摘要

Decisions regarding selection of components are crucial in the early phases of dosage form design yet it remains unclear how to determine a priori the optimal features required in a transdermal delivery system to best overcome the barrier properties of skin. Nifedipine (N) does not penetrate the skin at rates sufficint to permit clinically useful transdermal application, presumably due to its poor solubility in both lipophilic and hydrophilic media. Earlier studies showed that N penetration into the deeper layers of the skin was not favorable dur to the markedly poor affinity for systems structured by extensive hydrogen bonding. Thus, a certain enhancer considered appropriate for plar compounds, might be considered less apprpriate for nonpolar permeants.