Integrated endoscopic OCT system and in-vivo images of human internal organs

摘要

Abstract: First results of endoscopic applications of opticalcoherence tomography (OCT) for in vivo studies of humanmucosa in respiratory, gastrointestinal, urinary andgenital tracts are presented. A novel endoscopic OCT(EOCT) system has been created that is based on theintegration of a sampling arm of an all-optical-fiberinterferometer into standard endoscopic devices usingtheir biopsy channel to transmit low-coherenceradiation to investigated tissue. We have studiedmucous membranes of esophagus, larynx, stomach, urinarybladder, uterine cervix and endometrium as typicallocalization for carcinomatous processes. Images oftumor tissues versus healthy tissues have been recordedand analyzed. Violations of well-defined stratifiedhealthy mucosa structure in cancered tissue isdistinctly seen by EOCT, thus making this techniquepromising for early diagnosis of tumors and preciseguiding of excisional biopsy. !16