On the Simultaneous Fitting for Tracer Delay and Dispersion in Cerebral Blood Flow Studies Using Oxygen-15 Water and PET

摘要

Simulations were used to evaluate the feasibility of simultaneous estimation of CBF, partition coefficient, tracer delay and dispersion in the one-compartment CBF model by curve fitting. Accuracy and precision of these estimates were investigated by means of sensitivity functions. Despite the considerable variability (up to 50%) in the △t and τ estimates, estimates of CBF were within 5% of their true values.