Development of a new clinical NIRS sensor for absolute quantification of cerebral oxygenation

摘要

Abstract: A breadboard NIR sensor system has been developed based on the novel Psuedo-Random Modulation/Resolution Enhancement Technique (PRM/RET) and using a medium power diode laser system. The breadboard sensor system has been used to measure the photon migration in a phantom model consisting of milk and additive inks. The result clearly demostrates the unique capability of the PRM/RET sensor system for high-resolution time-resolved spectroscopic measurement with a nanosecond resolution which is currently limited by the digitizer bandwidth. The data obtained from this experiment was analyzed to retrieve the optical parameters of the phantom quantitatively. Based on the performance of the breadboard system, a prototype system configuration is being designed to obtain over a few GHz bandwidth and a few tens of psec precision which will be applied for the simple and accurate retrieval of the cerebral optical properties. !19