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Laser-assisted cartilage reshaping: in vitro and in vivo animal studies

机译:激光辅助软骨重塑:体外和体内动物研究

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Abstract: Correction of cartilaginous defects in the head and neck area remains a challenge for the surgeon. This study investigated a new technique for laser-assisted cartilage reshaping. The pulsed 1.44 $mu@m Nd:YAG laser was used in vitro and in vivo experiments to irradiate cartilage to change it's shape without carbonization or vaporization of tissue. Two watts of average power in non contact manner was used to irradiate and reshape the cartilage. The extracted reshaped cartilage specimens underwent testing of elastic force with a computer assisted measurement system that recorded the changes in elastic force in the specimens from 1 hr to 11 days post-irradiation. An animal model of defective tracheal cartilage (collapsed tracheal wall) was created, allowed to heal for 6 weeks and then corrected endoscopically with the laser-assisted technique. The results of the in vitro and in vivo investigations demonstrated that it was possible to alter the cartilage and that cartilage would retain its new shape. The clinical significance of the technique is evident and warrants further animal studies and clinical trials.!8
机译:摘要:纠正头颈部的软骨缺损对外科医生仍然是一个挑战。这项研究调查了激光辅助软骨整形的新技术。在体外和体内实验中使用脉冲1.44μmNd:YAG激光照射软骨以改变其形状,而不会碳化或蒸发组织。以非接触方式使用两瓦的平均功率辐照并重塑软骨。使用计算机辅助测量系统对提取的重塑软骨标本进行弹性力测试,该系统记录了辐照后1 hr至11天的标本中弹力的变化。创建了有缺陷的气管软骨(塌陷的气管壁)的动物模型,使其愈合了6周,然后用激光辅助技术进行了内窥镜矫正。体外和体内研究的结果表明,可以改变软骨并且软骨将保持其新形状。该技术的临床意义是显而易见的,值得进一步的动物研究和临床试验。8

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