Pharmacokinetic studies of delta-aminolevulinic-acid-induced protoporphyrin IX build-up in some malignant tumors

摘要

Abstract: Laser-induced fluorescence was used for the monitoring of the $delta@- amino levulinic acid (ALA)-induce protoporphyrin IX (PpIX) build-up in nonmelanoma malignant tumors of the skin and some cancers in the head and neck region. An optical-fiber based point monitoring system was utilized in the recording of fluorescence spectral at different time intervals after the administration of ALA. In the cases of skin tumors ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumor ALA was administered intravenously. For the PpIX induction in the head and neck tumors the ALA was given orally. An example of a tumor fluorescence image is also presented.!22