Abstract: In order to develop tumor-localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT-DO1 and has a molecular formula of m-phthalyl-{[13,17-bispropanoic acid-3-ethenyl-8-formylethylidene-7- hydroxy-2,7,12,18-tetramethyl-porphyrinate]-manganese (III)]}-(3'-ethenyl-8'-
展开▼
