Reversible dynamic mechanics of hydrogels for regulation of cell behaviors

摘要

This study presents a potential strategy for on-demand, repeatedly reversible dynamic control of hydrogel mechanics with OMA via a dual-crosslinking mechanism.By demonstrating direct changes in encapsulated hMSC morphology in response to dynamic changes in hydrogel mechanics, a repeatedly reversible 3D cellular mechanosensing system has been established. This system provides a powerful tool with a wide range of stiffness tunability to investigate the role of dynamic changes in 3D substrate mechanics in mechanobiology, biological processes and tissue development.