Porous, Conductive Hydrogel Electrodes Designed to Improve the Recording Longevity of Neuroelectronic Interfaces

摘要

Data from Figure 1 are a key first step in elucidating the complex mechanism driving the pore size-dependent impact of STS on the activation state of the immune cells which initiate and drive gliosis. Future work will incorporate the use of primary microglial cells to investigate the effect of pore size on a wider range of activation states in a more biologically relevant cell type. Additionally, properties of the conductive hydrogel electrode prototypes presented here suggest that such materials may have the potential to replace stiff silicon and metallic materials as electrodes, though much work still needs to be done to demonstrate miniaturization of hydrogel electrode dimensions, in vivo neuronal recording capability, and translation into electrode arrays for large-scale, high density recording. Taken together, these results hold promise for a future coupling of these materials in the fabrication of a soft, conductive hydrogel electrode core within an immunomodulatory STS coating which may integrate with CNS tissue to enable neural recording over clinically relevant time frames.