Tailoring Gelation and Mechanical Properties of Fibrin-Based Extracellular Matrix Using Stimulus-Responsive Poly(Lactic-co-Glycolic Acid) Microgelator

摘要

In summary, this study demonstrates the stimulus-responsive PLGA microgelator that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus, compared to the fibrin gel formed by mixing fibrinogen and thrombin in solution. We believe that this stimulus-reactive system would be useful to culturing a wide array of cells in a desired microenvironment and delivering them to the target diseased tissues without concerning about the gelation time.