3D-printing patterned biocompatible hydrogels to promote angiogenic sprouting

摘要

We achieved proof-of-concept mechanical enhancement of the printed channels and designed new serpentine 3D models with selective, more compliant regions. However, more work is required on fine-tuning the printing parameters and seeding the endothelial cells in the heterogeneous hydrogel for observations of sprouting. For future directions, we will quantify the relationship between matrix stiffness and the amount of angiogenic sprouting. This work represents a preliminary step towards achieving robust angiogenic sprouting for engineered tissues.